Anthony Casarez
Chief Scientific Officer dGenThera
Seminars
Wednesday 24th February 2027
Engineering High-Fidelity Theranostic Pairs with Covalent Radiohalogens (F-18/I-131/At-211) to Improve Biodistribution, Tumor Retention & Clinical Translation
2:00 pm
- Designing covalent radiohalogen therapeutics with matched diagnostic–therapeutic pairs to improve predictive biodistribution and translational confidence
- Overcoming traditional limitations of chelated radiometals by reducing off-target accumulation and enabling blood-brain barrier penetration
- Presenting preclinical imaging and efficacy data showing remarkable tumor control and favorable safety profiles across small molecule and bioligand-tagged platforms
Wednesday 24th February 2027
Comparing Alpha vs Beta Radiation Range & Energy to Tumor Biology to Maximize Disease Coveragee
4:30 pm
- Assessing tumor size, architecture & target heterogeneity to determine whether short-range alpha or longer-range beta irradiation provides better disease coverage
- Leveraging beta crossfire or high-LET alpha irradiation to overcome differences in target density & spatial distribution
- Matching radionuclide half-life & dose rate to vector PK and tumor residence to ensure radiation is delivered while the targeting agent remains at the tumor
