Keeping the Patient in Mind: Building Preclinical Evidence That Better Supports Translation into Humans
9:00 am - Thursday 25th February 2027
- Work backwards from the intended patient population and clinical setting to determine which preclinical questions need to be answered before progressing an RLT towards human studies
- Interrogate where preclinical models accurately reflect human disease and where they fall short, using complementary evidence to strengthen confidence in translation
- Apply lessons from previous RLT development to generate preclinical evidence that better informs clinical study design, treatment delivery and the successful progression of next-generation candidates into patients
