Reinier Hernandez
Chief Technology Officer Archeus
In addition to serving as Archeus’ Chief Technology Officer, Reinier is an assistant professor of medical physics at the University of Wisconsin. He is a radiochemist with research interests focused on theranostics, targeted radionuclide therapy, and radio-immuno-oncology. He is the recipient of numerous academic awards, has an extensive publication record, and is the inventor on multiple patents for cancer treatment and imaging agents. He has a proven track record of designing novel cancer targeting agents and taking them from concept through in vitro and in vivo preclinical testing and into clinical translation. He has extensive experience developing and implementing diagnostic and therapeutic radiolabeling and radioanalytical methods using a broad range of isotopes in preclinical and clinical settings.
Seminars
This workshop will explore the latest advances in alpha, beta, and Auger emitters for targeted radiopharmaceutical therapy, highlighting isotopes such as actinium-225, lead-212, lutetium-177, terbium-161, radium-223, and iodine-125. Join your peers to examine how their unique radiation properties – range, energy, and DNA damage – can be leveraged to maximize tumor cell killing while minimizing salivary gland and kidney toxicity. Join this session to discover emerging isotopes that could expand the reach of radioligand therapy and enable treatment of tumors previously considered difficult or heterogeneous.
Discussion Points:
- Are you trying to get a bystander effect? If so, what isotope is best to choose to improve overall therapeutic efficacy?
- Alpha VS Beta emitters – Why move towards Alpha emitters when Beta emitters are more established?
- Why pick particular isotopes for particular targets? How to optimize this match for maximized on-target delivery and minimized off-target effects?
- Considering matching time on target with your isotope – how long before you deposit your dose?
- Considering daughter products that might emerge after initial isotope breakdown?
