Rachael Brake

Chief Scientific Officer Abdera Therapeutics

Rachael Brake brings more than 20 years of experience in the biopharmaceutical industry building and leading cross functional teams across basic and applied research, clinical and business development. Dr. Brake joined Abdera from Zephyr AI where she served as chief scientific officer. Previously, Dr. Brake was the chief scientific officer at Corbus Pharmaceuticals where she built and led a research and development team and advanced multiple oncology programs into clinical development. Prior to her work at Corbus, Dr. Brake spent 11 years at Takeda Oncology, most recently as head of U.S. medical affairs, oncology business unit and as vice president, global program leader, oncology therapeutic area. In these roles, Dr. Brake managed a portfolio of programs and cross-functional teams responsible for the preclinical and clinical exploration of various solid tumor drug candidates spanning diverse mechanisms of action. Prior to joining Takeda, Dr. Brake was a research scientist at Amgen where she held increasing levels of responsibility culminating in the site lead in Cambridge, MA for the therapeutic innovation unit.
Dr. Brake began her career as a research scientist at the Western Australian Institute for Medical Research and Woden Valley Hospital. She holds a Ph.D. in molecular biology and biochemistry from the University of Western Australia.

Seminars

Wednesday 25th February 2026
Translating PK & Dosimetry for Faster, Safer Phase 0/FIH Progression
9:15 am
  • Defining ABD147 PK and tumor uptake in murine DLL3 models
  • Translating preclinical dosimetry to human PBPK projections
  • Informing FIH dosing through interspecies PK/dosimetry scaling

New Company for 2026

Wednesday 25th February 2026
Radio-Optimized Vector Engineering (ROVEr™): Abdera’s Novel Design Strategy
3:45 pm
  • Optimizing pharmacokinetics to maximize tumor uptake and penetration while minimizing off-target exposure and systemic toxicities
  • Enhancing therapeutic precision by delivering potent alpha or beta-emitting radioisotopes to selectively destroy cancer cells
  • Expanding target scope to address both high- and low-expressing cancer cells, enabling broad applicability across diverse tumor types

New Company for 2026

Rachael Brake