Understanding the Effects of Radiopharmaceuticals on Immune-Mediated Responses & Isotope Comparison on Anti-Tumor Immunity
Time: 9:00 am
day: Conference Day Two
Details:
- Comparing the immunologic effects of clinically-relevant radiopharmaceutical isotopes on anti-tumor immunity
- Exploring poorly immunogenic tumors with intrinsic resistance to ICIs, combination with high LET, short-range alpha-emitters may prime adaptive CD8+ T cell recognition
- Outlining acquired resistance to ICIs, low doses of low LET, longer range beta-emitting RPT may provide tumor inflammation and tumor cell susceptibility needed to renew clonal expansion of existing tumor-specific CD8+ T cells and generate immunologic memory
